(Sep 22) The Old Dominion Monarchs beat the Virginia Tech Hokies as a 28.5 point home underdog.
(Oct 27) The Oregon State Beavers beat the Colorado Buffaloes as a 26.5 point road underdog.
(Nov 10) The UNLV Rebels beat the San Diego State Aztecs as a 24 point road underdog.
(Sep 15) The BYU Cougars beat the Wisconsin Badgers as a 23.5 point road underdog.
(Sep 15) The Akron Zips beat the Northwestern Wildcats as a 21.5 point road underdog.
(Nov 24) The Hawai'i Rainbow Warriors beat the San Diego State Aztecs as a 18 point road underdog.
(Aug 25) The Hawai'i Rainbow Warriors beat the Colorado State Rams as a 17 point road underdog.
(Nov 8) The Wake Forest Demon Deacons beat the NC State Wolfpack as a 17 point road underdog.
(Nov 24) The Charlotte 49ers beat the Florida Atlantic Owls as a 16.5 point road underdog.
(Sep 8) The East Carolina Pirates beat the North Carolina Tar Heels as a 16.5 point home underdog.
(Sep 1) The Villanova Wildcats beat the Temple Owls as a 15 point road underdog.
(Sep 8) The Eastern Michigan Eagles beat the Purdue Boilermakers as a 15 point road underdog.
(Sep 15) The Temple Owls beat the Maryland Terrapins as a 15 point road underdog.
(Sep 22) The Texas Tech Red Raiders beat the Oklahoma State Cowboys as a 14.5 point road underdog.
(Oct 13) The Tennessee Volunteers beat the Auburn Tigers as a 14.5 point road underdog.
(Sep 28) The Tulane Green Wave beat the Memphis Tigers as a 14.5 point home underdog.
(Nov 10) The Old Dominion Monarchs beat the North Texas Mean Green as a 14.0 point home underdog.
(Sep 8) The Colorado State Rams beat the Arkansas Razorbacks as a 14.0 point home underdog.
(Nov 24) The UNLV Rebels beat the Nevada Wolf Pack as a 14.0 point home underdog.
(Nov 3) The SMU Mustangs beat the Houston Cougars as a 14.0 point home underdog.
(Sep 1) The Cincinnati Bearcats beat the UCLA Bruins as a 14 point road underdog.
(Sep 8) The Kentucky Wildcats beat the Florida Gators as a 13.5 point road underdog.
(Oct 6) The San Diego State Aztecs beat the Boise State Broncos as a 13.5 point road underdog.
(Oct 13) The Michigan State Spartans beat the Penn State Nittany Lions as a 13.5 point road underdog.
(Sep 2) The North Carolina A&T Aggies beat the East Carolina Pirates as a 13 point road underdog.
(Oct 27) The Kansas Jayhawks beat the TCU Horned Frogs as a 13.0 point home underdog.
(Sep 15) The Troy Trojans beat the Nebraska Cornhuskers as a 13 point road underdog.
(Sep 1) The Hawai'i Rainbow Warriors beat the Navy Midshipmen as a 12.5 point home underdog.
(Oct 27) The California Golden Bears beat the Washington Huskies as a 12.0 point home underdog.
(Oct 20) The Purdue Boilermakers beat the Ohio State Buckeyes as a 12.0 point home underdog.
(Oct 13) The Liberty Flames beat the Troy Trojans as a 12.0 point home underdog.
(Oct 25) The Georgia Southern Eagles beat the Appalachian State Mountaineers as a 11.0 point home underdog.
(Nov 24) The Western Kentucky Hilltoppers beat the Louisiana Tech Bulldogs as a 10.5 point road underdog.
(Nov 10) The Minnesota Golden Gophers beat the Purdue Boilermakers as a 10.5 point home underdog.
(Nov 24) The Minnesota Golden Gophers beat the Wisconsin Badgers as a 10.5 point road underdog.
(Oct 6) The Northwestern Wildcats beat the Michigan State Spartans as a 10.5 point road underdog.
(Sep 15) The LSU Tigers beat the Auburn Tigers as a 10 point road underdog.
(Oct 6) The Iowa State Cyclones beat the Oklahoma State Cowboys as a 10 point road underdog.
(Nov 13) The Ball State Cardinals beat the Western Michigan Broncos as a 10.0 point home underdog.
(Nov 10) The Northwestern Wildcats beat the Iowa Hawkeyes as a 10 point road underdog.
(Sep 1) The BYU Cougars beat the Arizona Wildcats as a 10 point road underdog.
(Sep 8) The Maine Black Bears beat the Western Kentucky Hilltoppers as a 10 point road underdog.
Out of 447 games with spreads of 10 or higher, 42 teams, or 9.40% were able to pull off the outright victory.